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相关概念视频

Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
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The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...

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Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
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细胞内动力学和异型再进入孤立的犬肺静脉和左心房.

Chung-Chuan Chou1, Motoki Nihei, Shengmei Zhou

  • 1Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif 90048, USA.

Circulation
|June 2, 2005
PubMed
概括

研究了在心房动 (AF) 期间肺静脉快速激活的机制. 自发的释放和无otropic重新进入肺静脉袖子有助于AF.

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科学领域:

  • 心血管生理学心血管生理学
  • 心脏电生理学 心脏电生理学

背景情况:

  • 肺静脉 (PVs) 的快速激活在心房动 (AF) 期间很常见.
  • 驱动这些快速激活的潜在机制仍然不清楚.

研究的目的:

  • 阐明AF期间在PV中快速激活的机制.
  • 为了研究焦点放电和光伏系统的重新进入的作用.

主要方法:

  • 通过同时绘制膜电位 (Vm) 和细胞内 (Ca (i)) 地图,研究了单独的狗左心室 (LA) 和PV制剂.
  • 通过心房节奏和药理学药物诱导了快速激活.
  • 分析了电生理学数据并进行了组织学染色 (PAS).

主要成果:

  • 来自近端PVs的诱导焦点放电,周期长度受到氨酸和异二醇的影响.
  • 在焦放电点中观察到电压独立的自发Ca (i) 释放在Vm激活之前.
  • 在重新进入过程中,相位奇点聚集在PV-LA交叉点.
  • 在PV袖子和PV-LA连接处发现了PAS阳性细胞和心肌异性质/纤维化增加.

结论:

  • 肺静脉肌肉袖子可能表现出电压独立的Ca (i) 释放,导致焦点放电.
  • 具有PAS阳性的结状细胞可以促进焦点放电.
  • 不同类型的再进入,特别是在PV-LA交叉点,有助于快速激活.
  • 焦点放电和异性反入都与AF期间的光伏快速激活有关.