细胞内动力学和异型再进入孤立的犬肺静脉和左心房
Chung-Chuan Chou1, Motoki Nihei, Shengmei Zhou
1Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif 90048, USA.
Circulation
|June 2, 2005
概括
研究了在心房动 (AF) 期间肺静脉快速激活的机制. 自发的释放和无otropic重新进入肺静脉袖子有助于AF.
科学领域:
- 心血管生理学心血管生理学
- 心脏电生理学 心脏电生理学
背景情况:
- 肺静脉 (PVs) 的快速激活在心房动 (AF) 期间很常见.
- 驱动这些快速激活的潜在机制仍然不清楚.
研究的目的:
- 阐明AF期间在PV中快速激活的机制.
- 为了研究焦点放电和光伏系统的重新进入的作用.
主要方法:
- 通过同时绘制膜电位 (Vm) 和细胞内 (Ca (i)) 地图,研究了单独的狗左心室 (LA) 和PV制剂.
- 通过心房节奏和药理学药物诱导了快速激活.
- 分析了电生理学数据并进行了组织学染色 (PAS).
主要成果:
- 来自近端PVs的诱导焦点放电,周期长度受到氨酸和异二醇的影响.
- 在焦放电点中观察到电压独立的自发Ca (i) 释放在Vm激活之前.
- 在重新进入过程中,相位奇点聚集在PV-LA交叉点.
- 在PV袖子和PV-LA连接处发现了PAS阳性细胞和心肌异性质/纤维化增加.
结论:
- 肺静脉肌肉袖子可能表现出电压独立的Ca (i) 释放,导致焦点放电.
- 具有PAS阳性的结状细胞可以促进焦点放电.
- 不同类型的再进入,特别是在PV-LA交叉点,有助于快速激活.
- 焦点放电和异性反入都与AF期间的光伏快速激活有关.
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