在休息状态下延迟开始的下内心静脉透析稀释识别了低透的心肌
Jianwen Wang1, Theodore P Abraham, Josef Korinek
1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA.
Circulation
|June 2, 2005
概括
延迟的下内心稀释表明在静止心肌中早期的低 perfusion,甚至在墙壁运动异常出现之前. 这一发现有助于识别心肌血流减少的情况.
科学领域:
- 心脏病学 心脏病学
- 心肌输血成像 - - 心肌输血成像
- 缺血性心脏病是一种心脏病.
背景情况:
- 心肌放松是能源依赖的,在缺血期间,减少 perfusion 影响心下内脏能量供应.
- 渐进性缺血的早期阶段主要影响心下输液和能量基质的输送.
研究的目的:
- 为了测试推迟的下内心透析稀释可以功能性地识别区域性hypoperfused静止心肌的假设.
- 评估延迟稀释是否在缺血区域中先发生可检测的壁面运动异常.
主要方法:
- 在12只狗中,在1-2周内诱导渐进的左前下垂冠状动脉狭窄.
- 获取M模式组织多普勒图像 (心下和心下) 并测量开始变薄的时间 (TOTv和TOTt).
- 在hypoperfused和对照区域之间对心肌流量和活力染色的比较.
主要成果:
- 在受影响区域显著降低心下肌动脉流量 (P<0.05).
- 根据速度 (TOTv) 和厚度 (TOTt) 的稀释开始的时间都显著延长 (P<0.01).
- 延迟的下内心稀释确定了缺血区域,即使保留了外壁活力.
结论:
- 延迟开始的下内心稀释是休息肌肉中低的早期指标.
- 这种现象发生在局部墙壁运动异常发生之前.
- 这些发现表明,早期缺血变化的新功能标志物.
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