查对印度喀拉拉邦口腔癌死亡率的影响:一个集群随机对照试验
Rengaswamy Sankaranarayanan1, Kunnambath Ramadas, Gigi Thomas
1Screening Group, International Agency for Research on Cancer, Lyon, France. Sankar@iarc.fr
Lancet (London, England)
|June 7, 2005
概括
口腔视觉查显著降低了印度高危人群口腔癌死亡率. 这种干预有可能每年防止全球数千例口腔癌死亡.
科学领域:
- 公共卫生 公共卫生
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 口腔癌是一个重要的健康问题,特别是在发展中国家,烟草和酒精使用是主要的风险因素.
- 通过视觉查进行早期检测对于降低死亡率至关重要.
研究的目的:
- 评估一个集群随机对照试验对口腔癌死亡率的影响.
- 评估高风险人群中卫生工作者视觉查的有效性.
主要方法:
- 一个集群随机对照试验,涉及1996年至2004年的印度13个集群.
- 干预组接受了三轮口腔视觉检查;对照组接受了标准护理.
- 35岁以上的参与者有资格参加;查阳性个体被转介进行临床检查和治疗.
主要成果:
- 与对照组相比,干预组的口腔癌死亡率比率降低了0.79 (95% CI 0.51-1.22).
- 在男性烟草或酒精使用者 (0.57 [0.35-0.93]) 中,观察到口腔癌死亡人数显著减少.
- 干预组中发生了70例口腔癌死亡,而在烟草/酒精使用者中,对照组中发生了85例.
结论:
- 口腔视觉查是减少高风险人群口腔癌死亡率的有效策略.
- 这项研究表明,通过广泛的视觉查计划,有可能在全球范围内预防至少37,000例口腔癌死亡.
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