通过在西非采摘后的干预措施减少对致癌性黄毒素的暴露:基于社区的干预研究
P C Turner1, A Sylla, Y Y Gong
1Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK.
Lancet (London, England)
|June 7, 2005
概括
收获后的干预措施显著降低了西非村庄的偏毒素暴露. 自给自足农业的低技术方法可以降低受污染的花生引起的疾病风险.
科学领域:
- 食品安全 食品安全
- 公共卫生 公共卫生
- 菌类毒理学 菌类毒理学
背景情况:
- 毒素是真菌代谢产物,污染了撒哈拉以南非洲的主要食品.
- 暴露与肝癌和儿童生长障碍有关.
- 这项研究评估了收获后的措施,以减少花生中偏毒素的污染.
研究的目的:
- 评估收获后干预措施在减少阿弗拉托克辛暴露方面的有效性.
- 确定低技术方法是否可以减轻西非村庄的健康风险.
主要方法:
- 在几内亚的20个村庄进行了一项干预研究.
- 十个村庄实施了收获后措施;十个村庄作为控制.
- 在5个月的时间里,对600名个体测量了血液中的亚弗拉托克辛-阿尔伯明添加物.
主要成果:
- 在收获后的对照村庄中,阿弗拉托克辛 - 专蛋白水平显著增加.
- 干预村的阿杜克特水平稳定,在5个月后低于对照水平的50%.
- 在干预组中,不可检测的阿杜克度从2%增加到20%.
结论:
- 低技术的收获后干预措施有效地减少了对亚拉托克辛的暴露.
- 这些方法可以大大降低自给自足农业社区中与偏毒素污染相关的疾病负担.
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