自主功能是否将社会地位与冠状动脉风险联系在一起? 怀特霍尔二号研究的研究
Harry Hemingway1, Martin Shipley, Eric Brunner
1International Centre for Health and Society, Department of Epidemiology and Public Health, University College London Medical School, 1-19 Torrington Place, London WC1E 6BT UK. h.hemingway@ucl.ac.uk
Circulation
|June 9, 2005
概括
低社会地位与自主神经系统功能受损有关,增加冠心病风险. 这种自主功能障碍可能解释了社会地位和代谢综合征组成部分之间的联系.
科学领域:
- 心血管流行病学心血管流行病学
- 自主神经科学 自主神经科学
- 健康的社会决定因素
背景情况:
- 慢性压力和较低的社会地位与不良的代谢结果有关,这可能解释了较低社会阶层的冠状动脉风险更高.
- 人们越来越认识到自主神经系统在调解压力反应和代谢健康方面的作用.
研究的目的:
- 调查关于自主神经系统功能障碍将社会地位与冠状动脉风险因素联系在一起的假设.
- 在健康的职业队列中检查社会地位,自主功能,行为因素和代谢综合征之间的关联.
主要方法:
- 怀特霍尔II研究包括2197名45-68岁的男性公务员.
- 根据就业等级评估社会地位;使用心率变化 (HRV) 记录测量自主功能.
- 心理社会因素 (工作控制),行为因素 (吸烟,饮食等). ) 和代谢综合征的组成部分被评估.
主要成果:
- 较低的就业等级与心率变化 (HRV) 的减少显著相关,表明自主功能受损 (P<0.02).
- 不良的行为和心理社会因素,包括低职位控制,也与较低的HRV有关 (P<0.03).
- HRV与代谢综合征成分 (P<0.001) 呈现强烈的线性关联;代谢综合征的社会梯度是由自主功能,行为因素和工作控制解释的.
结论:
- 长期受损的自主功能可能是社会地位和冠状动脉风险的各种组成部分之间的关键联系.
- 这些发现表明,自主功能障碍有助于在不同社会层面观察到的健康差异.
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