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Updated: Jul 17, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

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Published on: February 15, 2016

合成 (-) - 四环素的合成

Mark G Charest1, Dionicio R Siegel, Andrew G Myers

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Journal of the American Chemical Society
|June 9, 2005
PubMed
概括

这项研究详细介绍了从酸中合成 (-) - 四环素的17个步骤的酶选择合成,实现了1.1%的总产量. 关键步骤包括Diels-Alder循环添加和立体选择性氧化,以有效生产抗生素.

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