"可挥发性"支持高通量有机合成
Richard A Houghten1, Yongping Yu
1Torrey Pines Institute for Molecular Studies and Mixture Sciences Inc., 3550 General Atomics Court, San Diego, California 92121, USA. houghten@tpims.org
Journal of the American Chemical Society
|June 16, 2005
概括
可挥发的固体支物通过完全分解和挥发来增强化学合成,只留下所需的产品. 这种方法提高了各种化合物的效率,包括和复杂分子.
科学领域:
- 有机化学 有机化学
- 材料科学 材料科学 材料科学
- 合成化学 合成化学
背景情况:
- 固相合成是有机化学中的一个关键技术.
- 目前的方法可以留下残留的固体支材料,使净化复杂化.
- 有效地去除固体支对于高纯度产品的隔离至关重要.
研究的目的:
- 介绍和证明"可挥发"固体支物的实用性.
- 为了提高固相合成的效率和纯度.
- 展示这些支器在合成各种化学实体中的应用.
主要方法:
- 开发和应用"易挥发"的基于的固体支和连接器.
- 使用分解和挥发来完全去除支.
- 测试合成小分子,和类药物的方法.
主要成果:
- "易挥发"的支物通过分解和挥发完全被移除.
- 最后的裂解步骤只产生了所需的合成产品.
- 该方法证明对一系列非循环,异循环和基化合物有效.
结论:
- "易挥发"的固体支物在合成化学方面取得了重大进展.
- 完全去除支架简化了净化,增加了产量.
- 这种方法增强了各种低分子量化合物和的合成.
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