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相关概念视频

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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通过对比性超声波分子成像对整合素表达的内源性和治疗性动脉生成的评估.

Howard Leong-Poi1, Jonathan Christiansen, Peter Heppner

  • 1Cardiovascular Imaging Center and Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA.

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概括

使用向微泡的分子成像可以评估缺血肢体的早期血管生长 (血管生成). 这种技术在组织 perfusion 改善之前对评估新疗法的有希望.

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科学领域:

  • 生物医学工程 生物医学工程
  • 分子成像学分子成像学
  • 再生医学是一种再生医学.

背景情况:

  • 评估早期血管新生反应对缺血和生长因子治疗的非侵入性评估至关重要.
  • 用对比度增强超声波 (CEU) 和向微气泡进行分子成像提供了一个潜在的解决方案.

研究的目的:

  • 评估使用具有整合素结合微气泡的向CEU用于评估早期血管性反应.
  • 确定这种方法是否可以监测内源性和治疗性动脉生成.

主要方法:

  • 后肢缺血在老鼠中被诱导,其中一半接受了纤维细胞生长因子-2 (FGF-2) 治疗.
  • 使用CEU输液成像和灭法测量血流和氧气张力.
  • 综合素表达 (alpha(v) 和alpha5beta1) 通过使用向的CEU和带有埃希斯塔丁涂层的微泡进行了评估.

主要成果:

  • 缺血症显著降低了血液流动和氧气张力.
  • 向的CEU在未经治疗和FGF-2治疗的缺血肌肉中检测到强烈的整合素表达在血流恢复之前.
  • 治疗FGF-2增强了血流恢复和整合素向的微泡信号强度.

结论:

  • 向的CEU可以在组织 perfusion 恢复之前评估动脉形成.
  • 整合素表达的分子成像是评估益血管性疗法的宝贵工具.