相关实验视频
Updated: Jun 23, 2026
09:36
Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
欧利斯塔特对肥胖青少年体重和身体组成的影响:一项随机对照试验
Jean-Pierre Chanoine1, Sarah Hampl, Craig Jensen
1Endocrinology and Diabetes Unit, British Columbia Children's Hospital, Vancouver, Canada. jchanoine@cw.bc.ca
JAMA
|June 16, 2005
概括
奥利斯塔特,结合生活方式的改变,显著有助于青少年的体重管理. 这种肥胖治疗方法在一年内改善了BMI和脂肪量减少,但副作用是可以控制的.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 肥胖问题研究研究
- 药理干预药理干预
背景情况:
- 儿童和青少年超重和肥胖的患病率不断上升.
- 在这种人口群体中,行为疗法对持续减肥的成功有限.
- 青少年肥胖症的药理疗法尚未得到充分探索.
研究的目的:
- 评估orlistat在青少年体重管理中的有效性和安全性.
- 评估orlistat对身体质量指数 (BMI) 和其他人类测量指标的影响.
- 调查orlistat对肥胖青少年代谢参数的影响.
主要方法:
- 多中心,随机,双盲,安慰剂对照试验.
- 在54周的时间里,参与了539名肥胖青少年 (年龄为12-16岁).
- 与低热量饮食,运动和行为治疗一起服用orlistat (120毫克三次) 或安慰剂.
主要成果:
- 与安慰剂相比,奥利斯塔特显著降低了BMI (0.55对0.31的增加,P = .001).
- 较高的百分比的orlistat接受者实现了≥5%和≥10%的BMI减少 (26.5%和13.3%对比15.7%和4.5%).
- 奥尔利斯塔特减少了脂肪质量和腰围,胃肠道不良事件更频繁.
结论:
- 作为生活方式干预措施的辅助,orlistat有效地改善了肥胖青少年的体重管理.
- 在这群人群中,一年的orlistat治疗没有显示出任何重大安全问题.
- 胃肠道副作用更常见于orlistat,但一般为轻度至中度.
相关概念视频
01:52Regression Toward the Mean
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
01:24Obesity
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
01:15Bioavailability Study Design: Healthy Subjects Versus Patients
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...