改善心肌细胞β-上腺素反应和信号与高血压运动训练在高血压的运动训练
Scott M MacDonnell1, Hajime Kubo, Deborah L Crabbe
1Department of Kinesiology, Temple University, Philadelphia, PA 19122, USA.
Circulation
|June 22, 2005
概括
运动训练通过增强β-上腺素受体响应性,改善了高血压大鼠的心脏功能. 这与GRK2水平的降低和关键循环蛋白质的改变有关.
科学领域:
- 心血管生理学心血管生理学
- 运动生理学 运动生理学
- 分子心脏病学分子心脏病学
背景情况:
- 心脏对β-上腺刺激的反应在压力过载引起的心脏缩中受损.
- 研究运动训练对自发高血压中β-上腺素受体响应的影响至关重要.
研究的目的:
- 为了确定运动训练是否会改变自发高血压中的β-上腺素受体响应.
- 检查β-上腺素受体对激酶GRK2和Ca2+循环蛋白脱敏的作用.
主要方法:
- 自发高血压大鼠 (SHR) 接受跑步机训练 (SHR-TRD) 或保持久坐 (SHR-SED). 年龄相匹配的Wistar京都 (WKY) 老鼠作为对照.
- 在异二醇 (ISO) 输注和节奏压力期间,使用Langendorff制剂评估左心室 (LV) 功能.
- 分析了心肌中GRK2,L型Ca2+通道,酸交换器,酸受体和索兰班酸化的水平.
主要成果:
- 运动训练没有改变平均血压,但在SHR中增加了LV壁厚.
- 与SHR-SED和WKY相比,SHR-TRD对ISO表现出更好的内热和热反应.
- 训练使GRK2水平正常化,并增加了SHR中的诺丁受体和索兰班的酸化.
结论:
- 运动训练增强了高血压中的β-上腺素反应能力,改善了心脏收缩性和放松.
- 降低GRK2丰富度和增加Ca2+循环蛋白的酸化可能会调解这些有益影响.
- 运动训练为高血压患者改善心脏功能提供了一个潜在的策略.
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