大动脉脉冲波速升高,是动脉硬的标志物,预测了功能良好老年人的心血管事件
Kim Sutton-Tyrrell1, Samer S Najjar, Robert M Boudreau
1Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA. Tyrrell@edc.pitt.edu
Circulation
|June 22, 2005
概括
较高的大动脉脉冲波速率 (aPWV),衡量动脉硬度,与老年人死亡率和心血管事件的增加有关. 这一发现突出了aPWV作为社区居住的老年人群健康结果的重要预测因素.
科学领域:
- 心血管医学 心血管医学
- 老年学是指老年学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 衰老与血管硬度增加和大动脉脉冲波速度 (aPWV) 相关.
- 升高的aPWV与临床环境中的死亡率有关,但在一般人群中没有广泛研究.
- 动脉硬是老年人心血管健康的关键指标.
研究的目的:
- 调查aPWV与社区老年人总死亡率之间的关联.
- 为了确定aPWV是否预测心血管 (CV) 死亡率和心血管事件.
- 在一般老年人群中评估aPWV的预后价值.
主要方法:
- 大动脉脉冲波速度 (aPWV) 测量了2488名健康,衰老和身体组成 (Health ABC) 研究的参与者.
- 参与者的死亡率,死亡原因和心血管事件 (心脏病,中风,心力衰竭) 被追踪了4.6年.
- 统计分析检查了aPWV四分位数与不良健康结果之间的关联,并对共变量进行了调整.
主要成果:
- 较高的aPWV水平与增加的总死亡率 (RR 1.5-1.7) 和心血管死亡率 (RR 2.1-3.0) 显著相关.
- 增加的aPWV也与冠状动脉疾病 (CHD) 和中风的更高发病率有显著联系.
- 这些关联在调整年龄,性别,种族,血压和先前存在的心血管疾病后仍然存在.
结论:
- 大动脉脉冲波速度 (aPWV) 是老年人动脉硬的重要标志物.
- 升高的aPWV独立地与社区居住的老年人心血管死亡率,心血管疾病和中风的增加有关.
- aPWV作为一个有价值的预测在一般老龄化人口的不良心血管结果.
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