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相关概念视频

Chemistry of Carbohydrates03:25

Chemistry of Carbohydrates

Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...
Membrane Carbohydrates01:30

Membrane Carbohydrates

The plasma membrane is a dynamic barrier composed of lipids, proteins, and carbohydrates. It is the epicenter of many cellular processes required for cell growth and survival. Carbohydrates have unique structural and chemical properties that help the plasma membrane to carry out its functions effectively.
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Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Membrane Carbohydrates01:30

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The plasma membrane is a dynamic barrier composed of lipids, proteins, and carbohydrates. It is the epicenter of many cellular processes required for cell growth and survival. Carbohydrates have unique structural and chemical properties that help the plasma membrane to carry out its functions effectively.
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通过人工受体对碳水化合物的分子识别:模仿蛋白质-碳水化合物复合体晶体结构中发现的结合基因.

Monika Mazik1, Hüseyin Cavga, Peter G Jones

  • 1Institut für Organische Chemie der Technischen Universität Braunschweig, Hagenring 30, 38106 Braunschweig, Germany. m.mazik@tu-bs.de

Journal of the American Chemical Society
|June 23, 2005
PubMed
概括

简单的非循环受体有效地模仿蛋白质-碳水化合物结合基因. 皮里米丁受体3对β-glucopyranosides具有很高的疗效,在分子识别中展示了成功的合成模仿.

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科学领域:

  • 超分子化学 超分子化学
  • 碳水化合物识别 碳水化合物识别
  • 化学生物学 化学生物学

背景情况:

  • 蛋白质与碳水化合物的相互作用在生物系统中至关重要.
  • 了解这些相互作用需要研究分子识别动机.
  • 合成受体可以提供对生物结合的见解.

研究的目的:

  • 使用合成受体模仿蛋白质-碳水化合物结合基因.
  • 为了研究基于新和胺的新型受体的识别特性.
  • 评估pyrimidine受体3对β-glucopyranosides的疗效. 为了评估pyrimidine受体3对β-glucopyranosides的疗效.

主要方法:

  • 受体-碳水化合物复合物的结晶学 (受体1和3与葡萄皮化物4a和4b).
  • 结合基因的分析和与蛋白质-碳水化合物复合物的比较.
  • 对胺素受体3对各种单糖的识别的评估 (4-6).

主要成果:

  • 基于环状和的受体成功地模仿了蛋白质-碳水化合物晶体结构的结合基因.
  • 观察到的识别动机与糖结合蛋白和分子建模研究中的识别动机具有显著的相似性.
  • 皮里米丁受体3作为β-glucopyranosides的受体表现出高的有效性.

结论:

  • 合成受体可以有效地复制复杂的生物结合基因.
  • 胺3受体是一种高效的分子工具,用于beta-glucopyranoside的识别.
  • 这项工作推动了研究碳水化合物相互作用的人工系统的设计.