金黄色葡萄球菌内心炎:医学进步的结果.
Vance G Fowler1, Jose M Miro, Bruno Hoen
1Duke University Medical Center, Durham, NC 27710, USA. vance.fowler@duke.edu
JAMA
|June 24, 2005
概括
黄金葡萄球菌是全球传染性内心炎 (IE) 的主要原因. 这项研究突出了S aureus IE和耐甲素S aureus (MRSA) IE患者特征的显著区域差异.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 心脏病学 心脏病学
背景情况:
- 由黄金葡萄球菌引起的传染性内心炎 (IE) 是一个重要的全球健康问题.
- 黄金色 IE 的全球流行率和区域变异在很大程度上仍未得到证实.
- 了解这些模式对于有效的公共卫生战略至关重要.
研究的目的:
- 调查国际上出现的与医疗保健相关的黄金菌IE和耐美西林黄金菌IE.
- 分析患者人口统计和S aureus IE的临床特征的区域差异.
主要方法:
- 一项前性观察队列研究,涉及1779名确定的IE患者.
- 这些数据是从16个国家的39个医疗中心收集的,这些医疗中心是2000年至2003年内心内膜炎前性队列研究 (ICE-PCS) 国际合作的组成部分.
- 住院死亡率是主要的结局指标.
主要成果:
- 黄金葡萄球菌被确定为IE中最常见的病原体 (31.4%的病例).
- 与医疗保健相关的S aureus IE是普遍存在的,具有显著的区域差异 (25.9%至54.2%).
- 甲素耐药性黄金色杆菌 (MRSA) 的IE率因地区而异,在美国和巴西最高.
结论:
- 黄金葡萄球菌是全世界感染性内心炎的主要原因.
- 在患有黄金色 IE 患者的特征上存在显著的区域差异.
- 需要进一步的研究来阐明这些观察到的区域差异的根本原因.
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