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Updated: Feb 10, 2026

Phase Transitions and Effect of Intermolecular Forces
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冠状动脉疾病的病理生理学

Peter Libby1, Pierre Theroux

  • 1Donald W. Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA. plibby@rics.bwh.harvard.edu

Circulation
|June 29, 2005
PubMed
概括

冠状动脉疾病 (CAD) 现在被理解为一种炎症状况,而不仅仅是胆固醇的积累. 治疗侧重于斑块稳定和炎症,以预防急性冠状动脉综合征 (ACS).

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Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
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