ATP是中枢神经系统中化学传感转导的媒介
Alexander V Gourine1, Enrique Llaudet, Nicholas Dale
1Department of Physiology, Royal Free and University College London Medical School, Rowland Hill Street, London NW3 2PF, UK. a.gourine@medsch.ucl.ac.uk
Nature
|July 8, 2005
概括
脑干化学传感器释放的腺三酸盐 (ATP) 调节呼吸,以应对二氧化碳增加. 这种ATP信号传递对于中央呼吸控制至关重要,类似于其在外周感官功能中的作用.
科学领域:
- 神经科学是一个神经科学.
- 身体生理学 身体生理学
- 生物化学 生物化学
背景情况:
- 细胞外腺三酸盐 (ATP) 是一种已知的信号分子,参与外周感官功能,包括疼痛,触觉和氧气感应.
- ATP通过激活 afferent神经纤维上的P2X和P2Y受体来调解这些外周感觉.
- 大脑干中的化学感应神经元对于调节呼吸至关重要,以维持血液气体平衡.
研究的目的:
- 为了研究ATP在脑干中中央化学传感转导中的作用.
- 为了确定ATP是否从骨髓化学敏感区域释放出来,以应对血液气体的变化.
- 评估阻断ATP受体对呼吸调节的影响.
主要方法:
- 通过增加二氧化碳 (pCO2) 的部分压力,刺激长髓腹部表面的化学敏感区域.
- 从这些特定的大脑干区域释放的ATP的测量.
- 在已确定的化学敏感部位对ATP受体 (P2X和P2Y) 的药理学阻塞.
- 评估受体阻塞对呼吸调节的影响.
主要成果:
- 动脉pCO2的增加引发了ATP从腹髓中化学敏感区域的快速释放.
- 在这些骨髓部位阻断ATP受体显著损害了呼吸的化学传感控制.
- 证明ATP信号传递是中央呼吸系统化学传感的关键组成部分.
结论:
- 在中枢神经系统中,ATP充当呼吸调节的关键信号分子.
- 这些发现扩展了ATP已知的功能,超越了外围感官作用,包括中央化学感官传导.
- 在感官系统中ATP的古老作用被保存为重要的生理过程,如呼吸控制.
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