年龄,大腿皮层稳定性和部骨折风险之间的关系
Paul M Mayhew1, C David Thomas, John G Clement
1Department of Medicine, University of Cambridge, Cambridge, UK.
Lancet (London, England)
|July 12, 2005
概括
衰老会增加关节骨折的风险,原因是大腿皮层变薄,特别是在女性身上. 走路负荷不足可能需要有针对性的炼来加强骨和防止跌倒.
科学领域:
- 整形外科 整形外科 整形外科
- 生物力学 生物力学
- 老年学是指老年学的学科.
背景情况:
- 骨折风险随着年龄的增长而大大增加,局部曲 (弹性不稳定) 是潜在的原因.
- 骨结构适应机械负荷;双脚运动中部超侧部负荷不足可能导致皮质稀薄.
- 研究与年龄相关的弹性不稳定性变化对于了解关节骨折触发因素至关重要.
研究的目的:
- 测量部部弹性不稳定性与年龄相关的增加.
- 为了确定与年龄相关的骨结构变化是否有助于关节骨折风险.
主要方法:
- 计算机断层扫描 (CT) 用于分析年龄在20-95岁之间的人77个近端股骨的股骨中部骨分布.
- 临界应力,弹性不稳定的门,是根据最负荷的皮层骨区域的几何性质和密度计算出来的.
主要成果:
- 正常的衰老导致额外后腿部部皮质显著稀薄,特别是在女性身上,厚度每十年下降6.4%.
- 在女性中,临界压力每十年下降13.2%,这表明她们对弹性不稳定性的敏感性增加.
- 这种与年龄相关的稀薄减少了股骨的能量吸收能力,独立于骨质疏松症,骨骨折患者表现出进一步的不稳定性.
结论:
- 老龄化会增加女性的部脆弱性,原因是超侧皮质负载不足,导致缩性稀薄.
- 步行可能不会足够地负担上肢部,这表明需要加强炼.
- 有针对性的运动干预可能会减轻与年龄相关的骨脆弱性,并减少部骨折的发生率.
相关概念视频
The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bones of the Lower Limb: Femur and Patella
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the neck...
Bones of the Lower Limb: Tibia and Fibula
The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
Changes in the Appendicular Skeleton with Age
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Degenerative Disc Disease I: Introduction
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...


