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化c-Jun与TCF4的相互作用调节了肠癌的发展

Abdolrahman S Nateri1, Bradley Spencer-Dene, Axel Behrens

  • 1Mammalian Genetics Laboratory, CR UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

Nature
|July 12, 2005
PubMed
概括

通过c-Jun N-终端激酶 (JNKs) 酸化原核蛋白c-Jun,增强其与TCF4的相互作用,促进肠道瘤的生长. 抑制这种相互作用减少了瘤的发展,突出了WNT驱动的瘤发生的关键调节机制.

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