Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Carbon Skeletons01:12

Carbon Skeletons

Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side chains...
The Fossil Record02:56

The Fossil Record

The fossil record documents only a small fraction of all organisms that have ever inhabited Earth. Fossilization is a rare process, and most organisms never become fossils. Moreover, the fossil record only exhibits fossils that have been discovered. Nevertheless, sedimentary rock fossils of long-lived, abundant, hard-bodied organisms dominate the fossil record. These fossils offer valuable information, such as an organism's physical form, behavior, and age. Studying the fossil record helps...
Radioactive Decay and Radiometric Dating02:48

Radioactive Decay and Radiometric Dating

Radioactivity is a spontaneous disintegration of an unstable nuclide and is a random process, as all the nuclei in the sample do not decay simultaneously. The number of disintegrations per unit time is called the activity (A), which is directly proportional to the number of nuclei in the sample. The decay constant (λ) is an average probability of decay per nucleus in unit time.

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Molecular cues from distinct neuron classes drive differential myelination in the neocortex.

Developmental cell·2026
Same author

Cell-state mapping reveals a reversible neuroblast accumulation in the aging mouse hippocampus.

bioRxiv : the preprint server for biology·2026
Same author

Sequestration of growth cone surface proteins by cytoplasmic Lrrtm2 induces <i>de novo</i> amygdala innervation by cerebral cortex associative neurons.

bioRxiv : the preprint server for biology·2026
Same author

Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors.

eLife·2026
Same author

Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons of the cerebral cortex.

Nature neuroscience·2025
Same author

Human brain organoids record the passage of time over multiple years in culture.

bioRxiv : the preprint server for biology·2025

相关实验视频

Updated: May 8, 2026

Stable Isotopic Profiling of Intermediary Metabolic Flux in Developing and Adult Stage Caenorhabditis elegans
12:10

Stable Isotopic Profiling of Intermediary Metabolic Flux in Developing and Adult Stage Caenorhabditis elegans

Published on: February 27, 2011

考古细胞生物学:碳测年法不仅适用于和恐龙.

Paola Arlotta1, Jeffrey D Macklis

  • 1MGH-HMS Center for Nervous System Repair, Department of Neurosurgery, Program in Neuroscience, Harvard Medical School, Massachusettes General Hospital, Boston, Massachusettes 02114, USA.

Cell
|July 13, 2005
PubMed
概括
此摘要是机器生成的。

研究人员开发了一种方法,通过跟踪碳-14 (14C) 的结合来确定人类细胞的出生日期. 这种技术利用了1950年代核试验的14C峰值,以在体内追溯地测定细胞的日期.

更多相关视频

Measuring Carbon-based Contaminant Mineralization Using Combined CO2 Flux and Radiocarbon Analyses
11:19

Measuring Carbon-based Contaminant Mineralization Using Combined CO2 Flux and Radiocarbon Analyses

Published on: October 21, 2016

Sampling and Pretreatment of Tooth Enamel Carbonate for Stable Carbon and Oxygen Isotope Analysis
07:57

Sampling and Pretreatment of Tooth Enamel Carbonate for Stable Carbon and Oxygen Isotope Analysis

Published on: August 15, 2018

相关实验视频

Last Updated: May 8, 2026

Stable Isotopic Profiling of Intermediary Metabolic Flux in Developing and Adult Stage Caenorhabditis elegans
12:10

Stable Isotopic Profiling of Intermediary Metabolic Flux in Developing and Adult Stage Caenorhabditis elegans

Published on: February 27, 2011

Measuring Carbon-based Contaminant Mineralization Using Combined CO2 Flux and Radiocarbon Analyses
11:19

Measuring Carbon-based Contaminant Mineralization Using Combined CO2 Flux and Radiocarbon Analyses

Published on: October 21, 2016

Sampling and Pretreatment of Tooth Enamel Carbonate for Stable Carbon and Oxygen Isotope Analysis
07:57

Sampling and Pretreatment of Tooth Enamel Carbonate for Stable Carbon and Oxygen Isotope Analysis

Published on: August 15, 2018

科学领域:

  • 细胞生物学 细胞生物学
  • 放射化学 放射化学是指辐射化学.
  • 人类生理学 人类生理学

背景情况:

  • 确定人体细胞寿命是具有挑战性的,因为缺乏方法来准确地标记细胞长时间的诞生.
  • 以前的细胞测年方法不足以进行长期的体内回顾性分析.

研究的目的:

  • 建立一种新的方法,以追溯确定活人细胞的出生年份.
  • 为了利用历史环境数据用于生物测年应用.

主要方法:

  • 使用碳-14 (14C),一种放射性同位素,在DNA复制过程中被纳入细胞.
  • 利用大气中14C水平的显著峰值,这是由于上世纪50年代的地面核武器试验造成的.
  • 测量特定细胞群体内的14C水平,以推断它们相对于14C峰值的复制时间.

主要成果:

  • 通过使用14C结合,证明了回顾性约会人类细胞的可行性.
  • 建立了细胞14C水平和历史大气14C峰值之间的相关性.
  • 为研究人类组织细胞循环和衰老提供了一个新的工具.

结论:

  • 14C方法为了解人类细胞动态和寿命提供了一种强大的方法.
  • 这种技术对老年学,再生医学和疾病研究具有重大意义.
  • 回顾性细胞出生日期为研究人类长期细胞过程开辟了新的途径.