相关实验视频

Updated: Nov 10, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

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NIPA定义了一种SCF类型的哺乳动物E3结合酶,该结合酶调节了线粒体进入的过程

Florian Bassermann1, Christine von Klitzing, Silvia Münch

  • 1Department of Internal Medicine III, Technical University of Munich, 81675 Munich, Germany.

Cell
|July 13, 2005
PubMed
概括

ALK的核相互作用伙伴 (NIPA) 形成了控制细胞循环进展的E3结合酶复合体. 这个复合体针对核环林B1进行降解,防止过早进入线粒分裂.

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

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The use of SC1 Pluripotin to Support mESC Self-renewal in the Absence of LIF05:58

The use of SC1 Pluripotin to Support mESC Self-renewal in the Absence of LIF

Published on: November 18, 2009

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Anaphase Promoting Complex00:50

Anaphase Promoting Complex

The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
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The Spindle Assembly Checkpoint02:19

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Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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