在猪模型中对心房血栓的分子磁共振成像
Elmar Spuentrup1, Bernd Fausten, Sylvia Kinzel
1Department of Diagnostic Radiology, Aachen Technical University, Aachen, Germany. spuenti@rad.rwth-aachen.de
Circulation
|July 13, 2005
概括
一种新的纤维素特异性对比剂EP-2104R,使得高对比度的分子向磁共振成像 (MRI) 能够对左心房血块进行选择性可视化.
科学领域:
- 心血管成像 - 心血管成像
- 分子成像学分子成像学
- 生物医学工程 生物医学工程
背景情况:
- 检测心内质量,包括瘤和血栓,带来了诊断挑战.
- 准确区分心内质量对于有效的患者管理至关重要.
研究的目的:
- 调查纤维素特异性对比剂EP-2104R的疗效,用于分子向磁共振成像 (MRI).
- 评估该药物在可视化左心房血块方面的能力.
主要方法:
- 慢性人类血栓植入了猪的左心房附属物.
- 分子MRI是在EP-2104R注射前后使用特定序列进行的.
- 图像分析包括对比度和噪声比率的计算和凝块可视化评估.
主要成果:
- 在对比前的MRI上无法检测出血栓.
- 在对比剂后,所有植入的心房血块都被选择性地可视化.
- 实现了高的对比度与噪声比率 (凝块/血液,29.7+/-8.0),表明成功的向成像.
结论:
- 纤维素特异性对比剂EP-2104R有助于选择性和高对比度可视化左心房血块.
- 使用EP-2104R的分子向MRI显示了改善心内血栓检测的前景.
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