阻塞性睡眠呼吸暂停综合征影响左心室透静功能:男性鼻腔连续正气道压力的影响
Miguel A Arias1, Francisco García-Río, Alberto Alonso-Fernández
1Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.
Circulation
|July 13, 2005
概括
阻塞性睡眠呼吸暂停综合征 (OSAS) 独立影响左心室透静功能. 鼻腔连续正气道压力 (nCPAP) 治疗可以逆转这些早期的透析异常在OSAS患者.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 内部医学 内部医学
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 越来越多地被认可为其系统性影响.
- 左心室透静功能障碍是未经治疗的OSAS的潜在后果.
- 在透缩异常中OSAS的独立作用需要进一步阐明.
研究的目的:
- 调查阻塞性睡眠呼吸暂停综合征 (OSAS) 作为左心室扩张性异常的独立风险因素.
- 测试鼻腔连续正气道压力 (nCPAP) 在改善OSAS患者的舒张功能方面的有效性.
主要方法:
- 一项前性,随机化,安慰剂控制,双盲交叉研究,涉及27名中年男性OSAS患者和15名健康对照.
- OSAS患者接受了12周的虚假nCPAP和12周的有效nCPAP.
- 在基线和每次治疗后,对心声学,血压和尿道类甲醇胺进行了评估.
主要成果:
- 在OSAS患者 (15/27) 中,与对照组 (3/15) 相比,基线透支异常更为普遍.
- 放松障碍是观察到的最常见的透缩异常.
- 有效的nCPAP治疗显著改善了E/A比率,并减少了额头肌减速和异体体松时间.
结论:
- OSAS 独立于其他危险因素,有助于左心室透静功能障碍.
- 慢性nCPAP疗法可以预防腹异常的进展.
- 在发生显著的结构变化之前,nCPAP可能会逆转OSAS患者早期的透析变化.
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