中性粒细胞的枯竭抑制了实验性腹腔大动脉动脉瘤的形成
Jonathan L Eliason1, Kevin K Hannawa, Gorav Ailawadi
1Jobst Vascular Research Laboratories, Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, USA.
Circulation
|July 13, 2005
概括
中性粒细胞枯竭显著减少了小鼠腹腔大动脉动脉瘤 (AAA) 的形成. 这种保护作用没有由矩阵金属蛋白酶-2或-9 (MMP-2/9) 介导,这表明AAA发展中的其他机制.
科学领域:
- 血管生物学 血管生物学
- 炎症研究 炎症研究
- 动脉样硬化研究 研究动脉样硬化
背景情况:
- 中性粒细胞与腹腔大动脉动脉瘤 (AAA) 病原发生有关.
- 矩阵金属蛋白酶-2和-9 (MMP-2/9) 是AAA中的关键矩阵降解酶.
- 中性粒细胞通过MMP-2/9在AAA形成中的作用需要进一步研究.
研究的目的:
- 测试中性粒细胞枯竭是否限制实验AAA形成.
- 为了确定中性粒细胞减少是否会改变AAA中的MMP-2或MMP-9水平.
主要方法:
- 实验性腹腔大动脉动脉瘤 (AAA) 在C57BL/6小鼠中使用大动脉弹性酶输液诱导.
- 使用抗中性粒细胞抗体 (抗PMN) 治疗实现了中性粒细胞枯竭.
- 评估了大动脉直径,组织炎症细胞透,MMP表达/活性.
主要成果:
- 中性粒细胞枯竭 (84%的减少) 显著减少了AAA发病率从67%降至8%,大动脉直径增加.
- 耗尽的组显示,中性粒细胞和巨细胞透到大动脉组织的减少.
- 两组之间没有观察到MMP-2或MMP-9mRNA,蛋白质或活性的显著差异.
结论:
- 循环中性粒细胞对于启动实验性AAA形成至关重要.
- 中性粒细胞枯竭通过独立于MMP-2/9.9的机制抑制AAA的发展.
- 减少炎症细胞的招募有助于中性粒细胞枯竭的保护作用.
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