倾斜定位对急性肺损伤儿童临床结果的影响:一项随机对照试验
Martha A Q Curley1, Patricia L Hibberd, Lori D Fineman
1Children's Hospital Boston, Medical-Surgical Intensive Care Unit, 300 Longwood Ave, Boston, MA 02115, USA. martha.curley@childrens.harvard.edu
JAMA
|July 15, 2005
概括
倾向性定位并没有改善儿科急性肺损伤患者的临床结果. 这项研究发现,在不使用呼吸机的日子里,躺卧和卧卧的位置之间没有显著的差异.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 呼吸系统医学 呼吸系统医学
- 临床试验 临床试验
背景情况:
- 在未经控制的研究中,俯卧姿势在改善儿科急性肺损伤 (ALI) 患者的氧化方面表现有前途.
- 然而,它对患有ALI儿童的临床结果的影响仍然未知.
研究的目的:
- 为了确定倾斜的定位是否改善了急性肺损伤的儿科患者的临床结果.
- 主要假设是,卧卧的位置会导致28天的无呼吸器日数比卧卧的位置多.
主要方法:
- 一个多中心,随机,受控试验,涉及102名患有ALI的儿科患者 (2周至18岁).
- 患者被随机分配到躺着或倾斜的位置,倾斜组每天保持20小时,长达7天.
- 没有呼吸机的日期至28日是主要的结果指标.
主要成果:
- 审判由于徒劳而提前停止.
- 在倾斜和卧卧组 (15.6 vs 15.8天) 之间没有观察到无呼吸器日的显著差异.
- 二次结果,包括死亡率,康复时间,无器官衰竭的日子和功能健康,也没有显示群体之间的显著差异.
结论:
- 在患有急性肺损伤的儿科患者中,俯卧并没有显著减少无呼吸器日数.
- 该研究得出的结论是,倾斜的定位对这个患者群体没有提供临床结果的好处.
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