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在前列腺癌的治疗中使用雄激素剥夺疗法
Nima Sharifi1, James L Gulley, William L Dahut
1Medical Oncology Clinical Research Unit, National Cancer Institute, Bethesda, MD 20892, USA.
JAMA
|July 15, 2005
概括
抗雄激素剥夺疗法 (ADT) 有效治疗晚期前列腺癌,但具有诸如热和骨密度下降等重大风险. 它在其他环境中的好处需要仔细考虑对生活质量的影响.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 前列腺癌是美国男性癌症死亡的主要原因.
- 抗雄激素剥夺疗法 (ADT) 是晚期前列腺癌的主要治疗方法,也是高风险局部疾病的辅助剂.
研究的目的:
- 系统地审查关于ADT对前列腺癌的风险和益处的证据.
- 检查ADT不良影响的临床管理.
主要方法:
- 从1966年到2005年3月,Medline对英语文学进行了搜索.
- 关键词包括"雄激素剥夺疗法"",激素治疗"和"前列腺癌".
- 文献审查侧重于临床相关性和受控研究设计.
主要成果:
- 在晚期前列腺癌中,ADT是有效的缓解疗法,并改善了高风险局部疾病的辐射结果.
- 在没有转移的局部治疗后,ADT对PSA升高的益处尚不清楚.
- 副作用包括性欲下降,阳,发热,骨质疏松症,代谢变化以及认知/情绪变化.
结论:
- ADT已经在管理先进和高风险局部前列腺癌方面发挥了重要作用.
- 在其他临床环境中,ADT的好处必须仔细权衡其实质性风险和对生活质量的影响.
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