相关实验视频

Updated: Aug 4, 2026

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
11:13

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Published on: November 29, 2013

在神经退行性小鼠模型中,Tau抑制改善了记忆功能

K Santacruz1, J Lewis, T Spires

  • 1Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Science (New York, N.Y.)
|July 16, 2005
PubMed
概括

即使在tau抑制后,神经纤维状结 (NFTs) 也会积累,但在小鼠模型中,认知缺陷和神经元损失是逆转的. 这表明,单独使用NFT可能不会导致病的神经退行.

更多相关视频

Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment10:24

Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

Published on: June 22, 2015

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology10:02

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology

Published on: May 28, 2017

相关概念视频

Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.