基于机械设备的方法来管理和治疗心力衰竭
Donna Mancini1, Daniel Burkhoff
1Division of Cardiology, Columbia University Medical School, New York, NY, USA.
Circulation
|July 20, 2005
概括
机械设备为晚期心力衰竭患者提供了新的希望,当药物失败时. 这些创新方法解决了潜在的机械问题,改善了结果,并重塑了左心室.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 医疗器械 医疗器械
背景情况:
- 晚期心力衰竭与左心室功能障碍呈现出显著的发病率和死亡率,尽管药物治疗.
- 慢性机械压力和神经激素激活驱动不适应性心室重塑,这是疾病进展的关键因素.
- 当前药理疗法的局限性需要探索替代治疗策略.
研究的目的:
- 审查基于机械设备的方法来管理晚期心力衰竭.
- 突出产品在解决血动力学和机械异常方面所具有的潜力,这些异常无法通过药理学药物来解决.
- 讨论设备在促进反向改造和改善患者治疗结果方面的作用.
主要方法:
- 关于高级心力衰竭的基于机械设备的治疗方法的当前文献的综述.
- 对调查左心室辅助器件 (LVAD) 使用及其对心室改造的影响的研究分析.
- 探索用于患者监测和末期疾病支持的新兴设备.
主要成果:
- 左心室辅助装置 (LVAD) 的使用与深刻的逆向重塑有关,验证了基于设备的干预措施.
- 机械设备可以针对当前药物无法解决的基本病理生理异常.
- 目前正在调查一系列设备,从监测系统到对末期患者的支持.
结论:
- 基于机械设备的方法对于管理日益增长的高级心力衰竭患者群体至关重要.
- 需要对基于设备的策略进行进一步的研究,以实现更完整和永久的心脏恢复.
- 基于设备的疗法将在未来的心力衰竭治疗中发挥越来越重要的作用.
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