在健康的老年人中,有氧能力的纵向加速下降
Jerome L Fleg1, Christopher H Morrell, Angelo G Bos
1Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. flegj@nhlbi.nih.gov
Circulation
|July 27, 2005
概括
有氧能力随着年龄的增长而下降,在后来的几十年里显著加快,特别是在男性中. 这会影响功能独立和生活质量,尤其是在与疾病相结合时.
科学领域:
- 老年学是一门学科.
- 心血管生理学心血管生理学
- 运动科学 运动科学
背景情况:
- 老年人的独立生活依赖于有氧能力和力量.
- 峰值有氧能力 (峰值VO2) 随着年龄的增长而下降,但由于依赖横截面数据,以前的估计可能是不准确的.
研究的目的:
- 为了确定峰值有氧能力 (峰值VO2) 的纵向变化率.
- 研究年龄,性别和身体活动对这些与年龄相关的变化的影响.
主要方法:
- 在375名女性和435名男性 (年龄在21-87岁) 中,在平均7.9年内对峰值氧气消耗 (峰值VO2) 进行了连续测量.
- 一个线性混合效应回归模型分析了每十年峰值VO2的纵向变化.
- 对休时间的体力活动进行了调整.
主要成果:
- 在所有几十年的年龄段中,在两性中都观察到高峰VO2的持续纵向下降.
- 随着年龄的增长,衰退的速度显著加快,从20年代-30年代的每十年3-6%,到70年代的每十年20%以上.
- 从40多岁开始,男性的下降幅度比女性更大,并没有受到体力活动水平的显著影响.
结论:
- 峰值有氧能力下降的速度随着年龄的增长而加快,这与横截面研究的假设相反.
- 这种加速下降,特别是在男性中,对维持功能独立性和老龄化人口的生活质量有重大影响.
- 这些发现对于了解衰老和潜在的与疾病有关的影响对有氧能力至关重要.
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