巧拉波德阳离子受体对基质的歧视:几何效应和"亲和选择性原理"
John P Clare1, Alan J Ayling, Jean-Baptiste Joos
1School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
Journal of the American Chemical Society
|July 28, 2005
概括
新的类离子受体在非极地环境中表现出高亲和力结合和对离子的选择性. 它们的结合强度会影响选择性,这种现象被称为"亲和力-选择性",对超分子化学有着广泛的影响.
科学领域:
- 超分子化学 超分子化学
- 有机化学 有机化学
- 化学生物学 化学生物学
背景情况:
- 乔拉波德离子受体在非极性介质中结合具有高亲和力的离子.
- 这些受体已经证明了跨生物膜的阴离子运输.
研究的目的:
- 为了扩大巧拉波德离子受体的建筑范围.
- 为了研究阴离子结合中的结构选择性关系.
- 探索受体强度对阳离子选择性的影响.
主要方法:
- 合成了八个新的类离子受体,其中最多有六个H键捐赠中心.
- 应用克拉姆的提取方法来评估结合亲缘关系.
- 测试湿中与七个单价离子的结合.
主要成果:
- 对于几种受体-离子配对,取得了超过10^10 M^-1的关联常数.
- 观察到选择性取决于受体几何和强度.
- 确定了一个"亲和力-选择性"效应,更强的受体表现出更广泛的结合自由能量.
结论:
- 受体结构和强度是离子选择性的关键决定因素.
- 由H键强度产生的"亲和性-选择性"效应是超分子结合的重要因素.
- 研究结果为设计用于各种应用的选择性离子受体提供了洞察力.
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