治疗更年期症状:我们现在该怎么办?
Martha Hickey1, Susan R Davis, David W Sturdee
1University of Western Australia, School of Women's and Infants' Health, King Edward Memorial Hospital, Subiaco, Western Australia 6008, Australia. mhickey@obsgyn.uwa.edu.au
Lancet (London, England)
|August 2, 2005
概括
激素替代疗法 (HRT) 仍然有效治疗更年期症状,如热,但替代方案的证据有限. 雌激素或雌激素-孕激素是最有效的,而非激素选择显示的益处最小.
科学领域:
- 更年期管理管理
- 药理学 药理学是指药理学的学科.
- 基于证据的医学是基于证据的医学.
背景情况:
- 由于安全问题,激素替代疗法 (HRT) 的使用正在下降.
- 对更年期症状的替代治疗方法的兴趣增加.
- 难以评估用于HRT替代方案的证据.
研究的目的:
- 审查经常处方更年期治疗的疗效,风险和益处.
- 为管理更年期症状提供基于证据的临床指南.
- 为了比较荷尔蒙和非荷尔蒙治疗选择.
主要方法:
- 对更年期症状治疗的研究进行系统审查.
- 对各种疗法的安全性和有效性数据的分析.
- 对比研究和临床试验证据的评估.
主要成果:
- 雌激素或雌激素-孕激素组合对于发热和阴道干燥是非常有效的.
- 蒂博隆的疗效与HRT相当,可以改善性欲.
- 非激素选择,包括选择性血清素再吸收抑制剂,提供有限的短期益处.
- 补充疗法缺乏足够的证据来证明其在控制血管运动症状方面的有效性和安全性.
结论:
- 荷尔蒙疗法,特别是以雌激素为基础的治疗和tibolone,仍然是更年期症状管理中最有效的选择.
- 非激素治疗的疗效有限,尤其是在长期使用时.
- 需要进一步的研究来确定补充疗法的安全性和有效性.
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