相关实验视频
Updated: May 4, 2026

09:54
Live-imaging of the Drosophila Pupal Eye
Published on: January 12, 2015
9.2K
阿戈斯基因编码了一种可扩散因子,该因子调节了Drosophila眼中的细胞命运决定
M Freeman1, C Klämbt, C S Goodman
1Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Cell
|June 12, 1992
概括
德洛索菲拉阿尔戈斯基因对眼睛发育至关重要,调节细胞的确定性. 突变导致神秘细胞成为光受体,招募额外的细胞.
科学领域:
- 发育生物学是发展生物学.
- 遗传学 是一个遗传学.
- 细胞生物学 细胞生物学
背景情况:
- 阿戈斯基因在虫眼睛发育中起着至关重要的作用.
- 细胞命运的适当调节对于复杂组织的形成至关重要.
研究的目的:
- 为了研究阿尔戈斯基因在Drosophila眼睛发育中的功能.
- 了解阿尔戈斯介导细胞命运调节的基础细胞机制.
主要方法:
- 对阿尔戈斯突变Drosophila眼睛的发育分析.
- 克隆分析以确定阿尔戈斯作用的模式.
主要成果:
- 阿尔戈斯是生命力所必需的,并调节Drosophila眼中的细胞决定.
- 阿尔戈的突变导致神秘细胞转化为额外的光受体.
- 在阿尔戈斯突变者中招募了多余的形和色素细胞.
- 阿尔戈斯的作用非自主,扩散在几个细胞直径.
- 概念翻译表明,argos编码了一个分泌的蛋白质.
结论:
- 阿戈斯作为一种分泌的信号分子,在眼睛发育过程中调节细胞命运决策.
- 失去阿戈斯功能会破坏正常细胞的招募和分化途径.
- 阿尔戈的非自主作用凸显了它在眼睛发育中的细胞间通信中的作用.
更多相关视频
相关概念视频
Genetic Lingo
84.7K
Overview
84.7K
Mutation, Gene Flow, and Genetic Drift
53.1K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
53.1K
Position-effect Variegation
5.6K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
5.6K
Background and Environment Affect Phenotype
5.8K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
5.8K
The Ratio of X Chromosome to Autosomes
11.5K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
11.5K
Exon Recombination
3.1K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon...
Exon shuffling follows “splice frame rules.” Each exon...
3.1K

