在垂体细胞中和的作用潜力
B Biales1, M A Dichter, A Tischler
1Department of Neurology and Pathology, beth Israel Hospital/Harvard Medical School, Boston, Massachusetts 02215, USA.
Nature
|May 12, 1977
概括
内分泌细胞产生动作潜力. 研究人员发现,GH3垂体细胞使用 (Na) 和 (Ca) 机制进行电刺激,这也在人类垂体瘤中观察到.
科学领域:
- 神经内分泌学神经内分泌学
- 细胞电生理学 细胞电生理学
- 分子生理学分子生理学
背景情况:
- 内分泌细胞及其瘤可以表现出类似神经元的作用潜力.
- 以前的研究表明, (Ca) 是GH3垂体细胞中的主要机制.
- 上腺细胞主要依赖 (Na) 作为作用潜力.
研究的目的:
- 重新调查GH3大鼠垂体细胞中潜在的动作潜力的离子机制.
- 为了比较人类垂体瘤的电刺激性与大鼠垂体细胞系.
- 阐明Na和Ca在内分泌细胞活性潜能生成中的作用.
主要方法:
- 电生理学记录 (补丁) 的GH3细胞.
- 在人体垂体瘤细胞的体外培养.
- 离子操纵实验以确定离子通道贡献.
主要成果:
- 在生理条件下,GH3细胞中的作用电位取决于Na和Ca电流.
- 在GH3细胞中的电刺激机制不同于上腺胺细胞中主要依赖Na的机制.
- 在两个人体垂体瘤中观察到类似的电刺激模式.
结论:
- 在GH3垂体细胞中产生动作潜能涉及Na和Ca机制的协同作用.
- 这些发现表明,在垂体细胞中,电刺激的机制得到保护,延伸到人体瘤组织.
- 了解这些机制对于内分泌细胞功能和瘤发生研究至关重要.
相关概念视频
Osmosis
Approximately 60% to 95% of the weight of living organisms is attributed to water. Therefore, maintaining appropriate water balance within cells is of paramount importance. Osmosis is the movement of water across a semipermeable membrane, such as a cell’s plasma membrane. In living organisms, water plays a crucial role as a solvent—a molecule that dissolves other molecules.Diffusion Versus OsmosisBoth diffusion and osmosis are types of passive transport—cellular transport that does not require...
What are Membranes?
A cell's plasma membrane demarcates the cell's borders and determines the nature of its interaction with the environment. Cells exclude certain substances, take in others, and excrete some others in controlled quantities. The plasma membrane must be flexible to allow certain cells, such as red and white blood cells, to change their shape while passing through narrow capillaries. These are the more obvious plasma membrane functions. In addition, the plasma membrane's surface carries markers that...
Membrane Fluidity
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Enlargement of the Plasma Membrane
Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
Cell Motility through Blebbing
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
Cell Adhesion Molecules - Types and Functions
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...
CAM Families
The Integrin family of proteins is primarily involved in a...


