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在体外通过cordycepin 5'-三酸盐对染色质相关的多A合成的特定抑制

K M Rose1, L E Bell, S T Jacob

  • 1Department of Pharmacology, Milton S. Hershey Medical Centre, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA.

Nature
|May 12, 1977
PubMed
概括

科迪塞5'-三酸盐 (3'dATP) 在体外选择性地抑制了mRNA的初始多基化. 这种药物还抑制了RNA合成,与染色质结合的RNA聚合酶I比RNA聚合酶II更敏感.

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