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Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
在40岁以下的人群中,基底细胞和状细胞癌的发生率
Leslie J Christenson1, Theresa A Borrowman, Celine M Vachon
1Department of Dermatology, Mayo Clinic, Rochester, Minn 55905, USA.
JAMA
|August 11, 2005
概括
在年轻人中,非黑色素瘤皮肤癌的发病率正在上升,尤其是女性的基底细胞癌. 这一趋势凸显了针对年轻人群的皮肤癌预防策略的迫切需要.
科学领域:
- 皮肤病学 皮肤病学
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 非黑色素瘤皮肤癌 (NMSC) 的发病率正在增加,特别是在老年人群中.
- 关于40岁以下人群中NMSC发病率的数据有限.
研究的目的:
- 在40岁以下的个体中确定基底细胞癌 (BCC) 和状细胞癌 (SCC) 的性别和年龄特定发病率.
- 分析随着时间的推移,BCC和SCC发生率的趋势.
- 描述年轻成年人中这些瘤的临床表现,复发,转移和组织学.
主要方法:
- 以人口为基础的回顾性发病情况审查.
- 通过罗切斯特流行病学项目,利用了明尼苏达州奥姆斯特德县的综合医疗记录.
- 包括在1976年至2003年间被诊断患有BCC或SCC的40岁以下患者.
主要成果:
- 451个BCC和70个SCC在40岁以下的个人中被诊断出.
- 在女性 (25.9/100,000) 中,BCC发病率显著增加,但在男性 (20.9/100,000) 中没有增加.
- 在女性 (3.9/100,000) 和男性 (3.9/100,000) 中,SCC发病率显著增加.
结论:
- 在明尼苏达州奥姆斯特德县的年轻成年人中,NMSC的发病率正在增加.
- 在年轻女性中观察到BCC的不成比例增加.
- 这些发现强调了预防年轻人的皮肤癌的重要性,因为长期可能增加NMSC的发生率.
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