宿醉基因定义了乙醇耐受性发展所需的压力途径
Henrike Scholz1, Mirjam Franz, Ulrike Heberlein
1Department of Anatomy, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany. henrike.scholz@biozentrum.uni-wuerzburg.de
Nature
|August 12, 2005
概括
一个新的基因 - - 宿醉,对于果发展酒精耐受性至关重要. 这一发现揭示了两种不同的途径参与了耐受性,包括细胞应激反应,这表明跨物种的保护机制.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 重复饮酒会导致耐受性,身体依赖性和成.
- 甜虫 (Drosophila melanogaster) 作为一个模型生物体,表现出与哺乳动物相似的动力学与乙醇耐受性.
- 众所周知,这种耐受性涉及catecholamine octopamine,这是哺乳动物noradrenaline的功能模拟物.
研究的目的:
- 确定涉及乙醇耐受性发展的新型遗传因素.
- 为了阐明Drosophila中乙醇耐受性背后的分子途径.
- 研究细胞应激反应在药物耐受性中的作用.
主要方法:
- 在Drosophila中进行遗传选,以确定影响乙醇耐受性的突变.
- 行为测试用于测量乙醇耐受性和对环境压力因素 (热量,) 的反应.
- 基因表观测试测试,以确定基因和通路之间的关系.
主要成果:
- 一个新的基因,宿醉,被确定为正常乙醇耐受性发展的关键.
- 宿醉突变者在对各种环境压力因素的反应中表现出缺陷.
- 德洛索菲拉的乙醇耐受性被证明取决于两个不同的途径:一个涉及宿醉的细胞应激途径和一个涉及八胺的平行途径.
- 宿醉对核指蛋白进行编码,表明它可能在核酸结合中发挥作用.
结论:
- 草虫的乙醇耐受性是由至少两个并行的分子通路调节的.
- 通过宿醉基因调解的细胞应激反应途径在乙醇耐受性中起着重要作用.
- 这些发现表明,保存的进化机制将细胞应激反应与药物耐受性和与成有关的行为联系起来.
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