相关实验视频
Updated: May 4, 2026

08:57
Optical Trap Loading of Dielectric Microparticles In Air
Published on: February 5, 2017
8.4K
电压门离子通道中的门电荷位移涉及到有限的跨膜运动
Baron Chanda1, Osei Kwame Asamoah, Rikard Blunck
1Departments of Physiology and Anesthesiology, David Geffen School of Medicine, UCLA, 650 Charles E. Young Dr. South, Los Angeles, California 90025, USA.
Nature
|August 12, 2005
概括
在电压导离子通道中的S4段在电压传感过程中不会穿过脂质双层. 这一发现挑战了先前的模型,并表明有限的S4跨膜运动是通道关的关键.
科学领域:
- 分子生物学分子生物学
- 生物物理学的生物物理.
- 神经科学是一个神经科学.
背景情况:
- 电压关闭的离子通道在刺激细胞中产生电脉冲.
- S4跨膜螺旋是主要的电压传感元件.
- 在电压关门期间S4跨膜运动的程度是有争议的.
研究的目的:
- 为了研究S4跨膜运动在Shaker K+通道中的大小.
- 阐明离子通道中电压感应的分子机制.
主要方法:
- 使用光共振能量转移 (FRET).
- 一种脂性离子Dipicrylamine作为一个FRET受体.
- 捐赠分子被附着在S4域的Shaker K+通道上的各种位置.
主要成果:
- 在电压变化时没有观察到过渡的光变化.
- 这表明S4段不会在脂质双层中转移.
- 13e的封锁电荷可以用有限的S4运动来解释.
结论:
- 在电压封闭过程中,S4段不会经历显著的跨膜运动.
- 提出了一种新的电压门的分子模型,可以容纳有限的S4运动.
- 这项研究阐明了离子通道中电压传感的机制.
相关概念视频
Voltage-gated Ion Channels
11.2K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
11.2K
Motional Emf
3.3K
Magnetic flux depends on three factors: the strength of the magnetic field, the area through which the field lines pass, and the field's orientation with respect to the surface area. If any of these quantities vary, a corresponding variation in magnetic flux occurs. If the area through which the magnetic field lines are passing changes, then the magnetic flux also changes. This change in the area can be of two types: the flux through the rectangular loop increases as it moves into the...
3.3K
Electrostatic Boundary Conditions in Dielectrics
2.1K
When an electric field passes from one homogeneous medium to another, crossing the boundary between the two mediums imparts a discontinuity in the electric field. This results in electrostatic boundary conditions that depend on the type of mediums the field propagates through.
Consider a case where both the mediums across a boundary are two different dielectric materials. Recall that the electric field and electric displacement are proportional and related through the material's permittivity....
Consider a case where both the mediums across a boundary are two different dielectric materials. Recall that the electric field and electric displacement are proportional and related through the material's permittivity....
2.1K
Ampere-Maxwell's Law: Problem-Solving
1.4K
A parallel-plate capacitor with capacitance C, whose plates have area A and separation distance d, is connected to a resistor R and a battery of voltage V. The current starts to flow at t = 0. What is the displacement current between the capacitor plates at time t? From the properties of the capacitor, what is the corresponding real current?
To solve the problem, we can use the equations from the analysis of an RC circuit and Maxwell's version of Ampère's law.
For the first part of the...
To solve the problem, we can use the equations from the analysis of an RC circuit and Maxwell's version of Ampère's law.
For the first part of the...
1.4K
Electrochemical Gradient and Channel Proteins: An Overview
4.9K
An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to...
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to...
4.9K
The Electrical Double Layer
241
In the region where two bulk phases meet, an intricate electric charge distribution arises due to charge transfer, ion adsorption, molecular orientation, and charge distortion. This complex distribution is commonly referred to as the electrical double layer.When a solid electrode interfaces with ions in an electrolyte solution, the speed of electron transfer dictates the rates of oxidation and reduction. The electrode acquires a charge through the escape of atoms into the solution as cations or...
241

