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在人类2型糖尿病中,ARNT/HIF1beta转基因表达变化和胰岛岛功能障碍的损失介导着ARNT/HIF1beta的损失

Jenny E Gunton1, Rohit N Kulkarni, SunHee Yim

  • 1Joslin Diabetes Center and Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA.

Cell
|August 13, 2005
PubMed
概括

转录因子ARNT水平的降低会损害葡萄糖刺激的胰岛素释放,并导致2型糖尿病中的β细胞功能障碍. 这一发现突出了ARNT的ARNT.

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