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Updated: Jun 11, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
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由于SR蛋白拼接因子ASF/SF2的失活,导致基因组不稳定

Xialu Li1, James L Manley

  • 1Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

Cell
|August 13, 2005
PubMed
概括

拼接因子ASF/SF2通过防止突变性R循环结构,意外地保持了基因组稳定性. 耗尽ASF/SF2会导致DNA损伤和突变,而RNase H可以抑制这些突变.

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