相关实验视频
Updated: Jan 8, 2026
01:19
Regulation of Hormone Secretion
6.0K
人类皮革肺植入:连续59名患者的结果
Sachin Khambadkone1, Louise Coats, Andrew Taylor
1Great Ormond Street Hospital, London WC1N 3JH, UK. khambs@gosh.nhs.uk
Circulation
|August 17, 2005
概括
穿皮肺植入 (PPVI) 为患有先天性心脏缺陷修复后肺吐的患者提供了低风险的解决方案. 这种手术显著改善了心脏功能和运动能力,减少了重新干预的需要.
科学领域:
- 心血管外科心血管外科
- 干预心脏病学 干预心脏病学
- 儿童心脏病学 儿童心脏病学
背景情况:
- 在使用管的儿童中,右心室外流通道 (RVOT) 的重建通常需要由于肺吐和狭窄而重新进行干预.
- 在婴儿和儿童时期的先天性心脏病修复可以导致长期的并发症,如肺部反和狭窄.
研究的目的:
- 评估通过皮肤进行肺植入 (PPVI) 的可行性和结果,在患有肺吐和/或先天性心脏病修复后狭窄症的患者中.
- 评估PPVI后的血液动力学改善,没有扩张,以及运动耐受性的变化.
主要方法:
- 在58名患者 (平均年龄为16岁) 进行了PPVI,患者有肺吐和/或狭窄.
- 关键的终点包括死亡率,血液动力学参数,扩张率和运动能力.
- 用心脏MRI和代谢运动测试来评估心室功能和运动耐受性.
主要成果:
- 在所有58名患者中成功进行PPVI,没有死亡率.
- 观察到右心室压力,RVOT梯度和肺反的显著降低.
- 心脏核磁共振显示,肺反分数,RV终端-透缩体积和左心室终端-透缩体积的显著改善,以及有效的RV中风体积的增加.
- 代谢性运动测试显示,在一组患者中,VO2max显著改善.
结论:
- 在RVOT重建后,PPVI是一种可行的低风险干预措施,用于管理RVOT重建后的肺吐和狭窄.
- 该程序导致心脏MRI定义参数和肺反的可量化的改善.
- PPVI导致患者运动能力的主观和客观增强.
相关概念视频
Regulation of Hormone Secretion
6.0K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
Humoral...
6.0K
Hormonal Regulation
47.7K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
47.7K
Overview of Secretory Vesicles
9.3K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
9.3K
Insulin Secretory Vesicles
6.3K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
6.3K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
2.1K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
Insulin and C-peptide are...
2.1K
Feedback Inhibition
56.8K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
56.8K