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Updated: Jul 17, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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对于CheA基因酶自酸化的动态机制:分子动力学模拟

Jian Zhang1, Yechun Xu, Jianhua Shen

  • 1Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.

Journal of the American Chemical Society
|August 18, 2005
PubMed
概括

这项研究揭示了ATP如何在细菌双组分系统 (TCS) 中充当酸捐赠剂和激活剂. ATP结合导致P4域的结构变化,为P1结合和随后的自酸化打开了盖子.

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