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Updated: Jul 15, 2026

Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking
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Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking

Published on: December 17, 2013

交换:通过连续触发乙基迁移来控制粉样β衍生的体外自我组装

Sonia Dos Santos1, Arunan Chandravarkar, Bhubaneswar Mandal

  • 1Ecole Polytechnique Fédérale de Lausanne (EPFL), Institute of Chemical Sciences and Engineering, CH-1015 Lausanne, Switzerland.

Journal of the American Chemical Society
|August 25, 2005
PubMed
概括

这项研究引入了一种新方法,使用切换中的顺序基迁移来观察多的折叠和自我组装. 这项技术有助于了解这些过程的启动和阻断,这些过程对退行性疾病至关重要.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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