由化物诱导的螺旋形状的基于奥利戈英多尔的折叠材料
Kyoung-Jin Chang1, Byung-Nam Kang, Min-Hee Lee
1Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University, Seoul 120-749, South Korea.
Journal of the American Chemical Society
|September 1, 2005
概括
新的oligolindole折叠体在离子存在时表现出螺旋式折叠. 这种折叠是由联结驱动的,并通过增加内醇单元的数量来增强,形成稳定的1:1复合体.
科学领域:
- 超分子化学 超分子化学
- 有机化学 有机化学
- 聚合物科学 聚合物科学
背景情况:
- 折叠体是合成的寡合体,模仿蛋白质的二次结构.
- 奥利戈因多尔是一种新型的折叠聚合物,在分子识别中具有潜在的应用.
研究的目的:
- 为了合成和表征具有不同数量的内醇环 (4,6和8) 的奥利戈因多尔.
- 为了研究在化物离子的存在下,这些化物的折叠特性.
- 为了阐明橄英多和化物之间的结合机制和固态度.
主要方法:
- 合成含有4,6和8个醇单元的醇醇.
- 核磁共振 (1H NMR) 谱学用于研究键和形状变化.
- 旋转框架重置效应光谱 (ROESY) 来确认螺旋堆叠.
- 紫外线/可见定位实验,以确定结合常数和固体测量.
主要成果:
- 在添加化物后,奥利戈因多尔在NH信号中表现出下场转移,在芳香信号中表现出上场转移,这表明结合和pi堆叠.
- 罗西的实验证实了化物诱导的螺旋结构的形成.
- 紫外线/可见光标配显示了1:1的复合形成在化物和化物之间.
- 关联常数随着内醇NH组的数量增加而增加,这表明结合亲和力增强.
结论:
- 在与化物离子复合后,橄英多尔采用螺旋形状.
- 螺旋式折叠是由内NH组和化物之间的结相互作用介导的.
- 结合亲和力与醇单元的数量直接相关,突出了它们作为阴离子受体的潜力.
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