MaP :编程基于的中光学矩阵的自我组装.
Maxim G Ryadnov1, Derek N Woolfson
1Department of Biochemistry, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, United Kingdom.
Journal of the American Chemical Society
|September 1, 2005
概括
研究人员开发了矩阵编程 (MaP) 来控制自组装纤维 (SAF) 的组装. 这些新型可以实现基于的纳米结构材料的自下而上的设计,具有多样化的架构.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 类化学 类化学
背景情况:
- 自组装纤维 (SAF) 是由两个互补的 (SAF-p1和SAF-p2a) 形成的线性,非分支结构.
- 现有的SAF系统缺乏编程能力,无法创建复杂的纳米结构.
研究的目的:
- 引入矩阵编程 (MaP) ,用于SAF的定向组装.
- 为了证明使用MaP来创建各种基于的纳米结构的能力.
- 为了阐明 MaP 成分的结构-功能关系.
主要方法:
- 设计和合成MaP,包括通过树突枢纽结合的半块.
- 与标准SAF一起组装MAP和标准SAF.
- 由此产生的纳米结构的表征 (例如,超分支网络,多角矩阵).
主要成果:
- MaP酸成功地将SAF组装到各种架构中.
- 特定的MaP型设计产生了超分支网络,多边形矩阵和细分纤维.
- 确定了单个半块对结构特征的贡献.
结论:
- MaP 为基于的纳米结构材料的自下而上的制造提供了一个多功能平台.
- 这种方法为设计具有定制性质的新纳米结构提供了坚实的基础.
- 了解半块的作用,可以精确控制材料架构.
更多相关视频
相关概念视频
02:41Protein Complex Assembly
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Many viruses self-assemble into a fully functional unit using the infected host cell to...
01:19Translocation of Proteins into the Mitochondria
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...