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在人类进化过程中Y链基因的保存,由黑猩猩的比较测序揭示出来
Jennifer F Hughes1, Helen Skaletsky, Tatyana Pyntikova
1Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.
Nature
|September 2, 2005
概括
人类Y染色体正在失去基因,但这项研究发现,独特的基因在人类中被保存. 相比之下,黑猩猩显示基因衰变,可能是由于精子竞争.
科学领域:
- 遗传学 遗传学 是一个
- 进化生物学 进化生物学
- 基因组学就是基因组学.
背景情况:
- 人类Y染色体的基因明显少于自体因其独特的进化路径.
- 预测表明,Y染色体可能在1000万年内失去所有功能基因.
- 独特的Y链基因的保存,而不是在Palindromes中,是理解Y染色体进化的关键.
研究的目的:
- 研究人类和黑猩猩中独特的Y链基因的保护.
- 通过检查基因衰变来测试Y染色体"即将死亡"的假设.
- 探索潜在的进化压力驱动基因丢失或保留.
主要方法:
- 对人类和黑猩猩之间独特的Y链基因的DNA序列进行系统比较.
- 对跨物种的基因保存和无活化突变的分析.
- 进化选择压力的评估,包括净化和积极选择.
主要成果:
- 检查的所有独特的Y链基因都在人类血统中保存,这表明净化选择.
- 几种独特的Y链基因在黑猩猩血统中维持了无活化突变.
- 有证据表明,黑猩猩的基因衰变可能与由精子竞争驱动的积极选择有关.
结论:
- 人类Y染色体的独特基因被积极保护,这挑战了"即将消失"的假设.
- 黑猩猩的基因衰变突出了Y染色体的血统特定的进化轨迹.
- 精子竞争可能是影响Y染色体进化的重要因素,在一些灵长类动物的血统.
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