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相关概念视频

Ribosomes01:27

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.Ribosome Structure and AssemblyRibosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within the...
Ribosomes01:27

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.Ribosome Structure and AssemblyRibosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within the...
Riboswitches01:56

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
Ribozymes02:47

Ribozymes

The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can be...
Ribozymes02:47

Ribozymes

The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can be...
Ribosomes01:27

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within...

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相关实验视频

Updated: Jul 13, 2026

Localized RNAi and Ectopic Gene Expression in the Medicinal Leech
16:19

Localized RNAi and Ectopic Gene Expression in the Medicinal Leech

Published on: April 17, 2008

通过分支进行封顶:一种新的 ribozyme 产生了微小的 lariats.

Anna Marie Pyle1

  • 1Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, 266 Whitney Avenue, Bass Building Room 334, New Haven, CT 06520, USA.

Science (New York, N.Y.)
|September 6, 2005
PubMed
概括

科学家们发现了一种新的分支 ribozyme,扩展已知的 RNA 酶. 这种新型酶与I组内有着令人惊的进化联系.

科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 在RNA催化过程中.

背景情况:

  • 自然存在的RNA酶或 ribozymes 在各种细胞过程中起着至关重要的作用.
  • 已知 ribozymes 的多样性在历史上一直是有限的,阻碍了对它们的催化潜力的充分理解.
  • I组内子是已知的催化RNA,参与RNA剪接和其他遗传操纵.

研究的目的:

  • 报告发现和描述一种新型分支 ribozyme 的情况.
  • 为了研究这种新型 ribozyme 的进化和机械关系.

主要方法:

  • 生物化学测试以确定催化活性.
  • 序列分析和遗传学比较.
  • 结构预测和功能域映射.

主要成果:

  • 鉴定了一种具有独特催化性能的新型分支 ribozyme.
  • 证明了新型 ribozyme 和 I 组内基子之间的意想不到的序列和结构相似性.
  • 遗传学分析表明一种潜在的进化联系.

结论:

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Last Updated: Jul 13, 2026

Localized RNAi and Ectopic Gene Expression in the Medicinal Leech
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Nanomanipulation of Single RNA Molecules by Optical Tweezers

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Chemical Triphosphorylation of Oligonucleotides

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  • 这种分支 ribozyme 的发现显著扩大了已知的 RNA 酶的多样性.
  • 这些发现表明,不同类型的核糖酶之间的进化关系比以前所认为的更为深入.
  • 这项工作为了解RNA进化和催化机制开辟了新的途径.