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正在进行的ASPM的适应性进化,ASPM是人类智人大脑大小的决定因素
Nitzan Mekel-Bobrov1, Sandra L Gilbert, Patrick D Evans
1Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
概括
人类大脑的进化正在进行中. 一种特定的基因变异,异常的状小头症 (ASPM),最近出现并迅速传播,表明最近的积极选择和持续的大脑适应.
科学领域:
- 人类进化人类的进化.
- 遗传学 是一个遗传学.
- 神经科学是一个神经科学.
背景情况:
- ASPM基因是大脑大小的关键调节者.
- 进化研究表明,在人类血统中,ASPM存在强烈的积极选择.
研究的目的:
- 为了研究特定的人类ASPM遗传变异的进化史.
- 为了确定最近人类大脑的进化是否仍在发生.
主要方法:
- 种群遗传学分析
- 遗传学上的推断.
- 在人类群体中分析ASPM基因变异.
主要成果:
- 一种特定的人类ASPM变种大约有5800年历史.
- 由于强烈的阳性选择,这种变异的频率迅速增加.
- 有证据表明,人类大脑正在进行适应性进化.
结论:
- 人类大脑继续快速发展.
- 最近ASPM的遗传变化突出显示了正在进行的适应.
- 发现了一个年轻的,精选的变体,为人类大脑进化提供了洞察力.
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