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血腺素,体重指数和慢性心力衰竭患者的死亡率
Caroline Kistorp1, Jens Faber, Søren Galatius
1Department of Cardiology and Endocrinology, Frederiksberg University Hospital, Copenhagen, Denmark. cnkistorp@dadlnet.dk
Circulation
|September 15, 2005
概括
高水平的阿迪波内克可以预测慢性心力衰竭 (CHF) 患者的死亡率,无论疾病的严重程度如何. 身体质量指数 (BMI) 也预测死亡率,可能由阿迪波涅克丁和NT-proBNP水平介导.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 更高的体重指数 (BMI) 与更好的慢性心力衰竭 (CHF) 预后有关.
- 阿迪波内克丁,一种与BMI相反的皮细胞因子,是健康个体的死亡率预测因子.
- 在CHF患者中,阿迪波涅丁与死亡率之间的关系需要进一步调查.
研究的目的:
- 研究慢性心力衰竭 (CHF) 患者血腺素水平和死亡率之间的关联.
主要方法:
- 一项前性研究,涉及195名心血管衰竭患者.
- 基线测量包括血腺素,N-终端脑前性尿素 (NT-proBNP) 和BMI.
- 死亡率数据采集在2.6年的中位数随访期间.
主要成果:
- 阿迪波涅克丁和NT-proBNP相互积极相关,与BMI负面相关.
- 高水平的阿迪波内克 (上层三角体) 预测死亡率,即使经过对心血管疾病严重性标志物和NT-proBNP (HR=3.23,P=0.032) 的调整.
- 体重指数 (BMI) 预测死亡率独立于心脏梗塞的严重程度,但在对NT-proBNP进行调整后失去了意义 (HR=0.74,P=0.13).
结论:
- 增加的阿迪波涅丁水平是慢性心血管疾病患者死亡的独立预测指标,可能表明衰竭.
- 体重指数和CHF死亡率之间的关联可能部分由阿迪波内克丁和NT-proBNP介导.
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