在诱导短期心脏记忆之前和之后,狗左心室的重极化梯度
Michiel J Janse1, Eugene A Sosunov, Ruben Coronel
1Center for Molecular Therapeutics, Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, USA. m.j.janse@amc.uva.nl
Circulation
|September 15, 2005
概括
心脏记忆缩短了心室再极化时间,特别是基梯度,影响T波配置. 在狗的左心室中没有发现过神经复极化梯度.
科学领域:
- 心血管生理学心血管生理学
- 心脏电生理学 心脏电生理学
背景情况:
- 研究复极化梯度在T波形成中的作用.
- 了解短期心脏记忆的电生理学基础.
研究的目的:
- 为了确定狗心室的跨毛线与基复极化梯度.
- 为了评估诱导心脏记忆后复极化的变化.
主要方法:
- 从狗的上心部和室内部位记录了单极电图.
- 测量激活时间和激活恢复间隔 (ARI).
- 记录了心表单相动作潜力.
主要成果:
- 没有观察到任何显著的左心室横向性复极化梯度.
- 基梯度存在:最短的反极化是在基前,最长的是在基后.
- 心脏记忆诱导均缩短复极化时间和作用电位持续时间.
结论:
- 再极化发生在狗心室中没有跨壁梯度.
- 基再极化梯度显著影响T波生成.
- 心脏记忆后缩短的再极化可能解释了心电图T波变化.
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