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Updated: Jul 18, 2026

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用于蛋白质折叠研究的糖化Im7模拟物的半合成

Christian P R Hackenberger1, Claire T Friel, Sheena E Radford

  • 1Department of Chemistry and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Journal of the American Chemical Society
|September 15, 2005
PubMed
概括

我们创建了一种新的方法来研究糖化如何影响蛋白质折叠,使用半合成方法对免疫蛋白Im7. 这种方法表明,糖基化不显著改变蛋白质.

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Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...