在间歇性血液和晶体性心脏之后,亡的分子指数
Jun Feng1, Cesario Bianchi, Jennifer L Sandmeyer
1Division of Cardiothoracic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Circulation
|September 15, 2005
概括
冷血间歇性心脏 (iC-BCP) 最好通过减少亡来保持心脏功能. 这种方法增强了坏酸化,抑制了酶3的激活和心肌细胞死亡.
科学领域:
- 心血管外科心血管外科
- 心脏麻醉心脏麻醉
- 心肌细胞生物学 心肌细胞生物学
背景情况:
- 心肌亡和相关蛋白质是心脏手术结果的关键因素.
- 研究间歇性血液与结晶性心的差异性影响对于优化心肌保护至关重要.
研究的目的:
- 为了比较间歇性血性心脏 (iBCP) 和间歇性结晶性心脏 (iCCP) 对心肌亡的影响.
- 评估这些心脏症解决方案对与亡相关的基因蛋白和心脏功能的影响.
主要方法:
- 子的心脏被使用兰根多夫装置间歇性热或冷晶体或血液心脏.
- 心脏经历了60分钟的心脏停止,随后进行了30分钟的再注血.
- 评估了左心室功能,微血管功能,蛋白质水平 (caspase3,Bcl-2,Bad,Bax) 和不良酸化.
主要成果:
- 与其他组相比,冷血间歇性心脏 (iC-BCP) 显著保留了左心室和微血管功能.
- 在caspase3,Bcl-2,Bad和Bax的总蛋白水平上没有发现显著差异.
- iC-BCP显著增加了不良酸化,并证明减少了caspase 3激活和亡.
结论:
- 冷血间歇性心脏 (iC-BCP) 在减轻心肌亡和保持心脏功能方面优越.
- 通过iC-BCP对Bad的增强酸化在抑制酶3激活和亡方面发挥着关键作用.
- 这些保护作用转化为改善左心室功能和冠状动脉微血管放松.
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