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基因表达程序的刺激特异性是由IKK活动的时间控制决定的

Shannon L Werner1, Derren Barken, Alexander Hoffmann

  • 1Signaling Systems Laboratory, Department of Chemistry and Biochemistry, 9500 Gilman Drive, Mailcode 0375, La Jolla, CA 92093-0375, USA.

Science (New York, N.Y.)
|September 17, 2005
PubMed
概括

不同的炎症刺激会触发不同的IkappaB激酶 (IKK) 活动概况. 这些由反机制调节的个人资料决定了特定的基因激活和对刺激的生物反应,例如脂多糖 (LPS) 和瘤亡因子-α (TNFalpha).

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